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板凳

楼主 |
发表于 2014-6-1 19:13:40
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Part III: Obstacle
Defining 'natural'
Nature 452/10 April 2008
[Paraphrase 7]
Visceral reactions to an act should not distract from the real ethical issues.
From an evolutionary perspective, we humans have good reason to be wary of things that seem to be 'unnatural'. Anything out of the ordinary can be dangerous. But the evolutionary origin of that response also guarantees that it will be guided more by emotion than by reason. Witness the reaction last week when Thomas Beatie, from Bend, Oregon, announced his pregnancy on the popular television talk show, Oprah.
Beatie, who was born female (and participated in beauty pageants), underwent hormone treatment and some gender-reassignment surgery ten years ago, but retained his reproductive organs. He stopped taking hormones so that he and his wife, who cannot bear children, could pursue artificial insemination. Several doctors turned them down, but last week, the world watched as a baby-faced man with a thin beard and a growing paunch went for an ultrasound: the fetus was a girl. Oprah Winfrey was supportive as she nursed the nervous Beatie through a discussion of his personal realizations. So was the lesbian, gay, bisexual and transgender community. But other reactions were vitriolic, as when MSNBC's Joe Scarborough repeatedly commented that he was "going to be sick". Other such visceral responses were common on message boards and blogs on the Internet, where the situation was often held to be disgusting and unnatural.
And yet, when we consider this story with the reasoning parts of our brains, exactly what was so 'unnatural'? The longing to have a baby? That is a profoundly human desire, whether the prospective parents are male, female or transgendered. Or is it that Beatie has acted on his certainty that he is a man who happened to be born without a Y chromosome? Biologists have found that gender-straddling and gender-switching behaviours are not at all uncommon in the 'natural' world, either for humans or non-human animals (see page 678). True, modern biotechnology has considerably raised the stakes, and is allowing humans to manipulate their biological make-up to an ever-increasing degree. But it hasn't fundamentally changed the game. And its applications, however unsettling they may be to some people, are not, by definition, 'unnatural'.
This same question of 'natural' versus 'unnatural' also emerges this week in a very different context: an online poll that Nature started in January on the use of neuroenhancing drugs (see page 674). Respondents were asked to report on their non-medical use of drugs such as modafinil and methylphenidate to improve their concentration. These drugs can have mild effects, not all that different from caffeine (a natural substance) or other stimulants. But somehow the 'unnaturalness' of these drugs makes some people uneasy in a way that caffeine does not. The claim, repeated in many responses to our survey is that using such drugs, or any performance-enhancing drug, makes accomplishments somehow less worthy because they aren't natural. But again, what is 'natural'? Devices such as glasses, hearing aids, pacemakers and artificial hips are unnatural. Yet they are widely accepted as legitimate ways to enhance the human experience. By the same token, if drugs enhance performance on a standardized test, what is so 'natural' about prep courses designed to improve scores?
Ultimately, our visceral concept of what is 'natural' depends on what we are used to, and will continue to evolve as technology does. But in the meantime, we should not allow it to distract us from the rational consideration of deeper and more important ethical issues. In the case of Beatie and his wife, the elemental questions are the health, safety and emotional security of the child. Trying to decide such issues simply by fixating on a fluid and arbitrary definition is, by nature, silly.
[614 words]
Source: nature
http://www.nature.com/nature/journal/v452/n7188/full/452665b.html
Going beyond X and Y
Babies born with mixed sex organs often get immediate surgery. New genetic studies, Eric Vilain says, should force a rethinking about sex assignment and gender identity.
May 20, 2007 |By Sally Lehrman
[Paraphrase 8]
When Eric Vilain began his medical school rotation two decades ago, he was assigned to France's reference center for babies with ambiguous genitalia. He watched as doctors at the Paris hospital would check an infant's endowment and quickly decide: boy or girl. Their own discomfort and social beliefs seemed to drive the choice, the young Vilain observed with shock. "I kept asking, 'How do you know?' " he recalls. After all, a baby's genitals might not match the reproductive organs inside.
By coincidence, Vilain was also reading the journals of Herculine Barbin, a 19th-century hermaphrodite. Her story of love and woe, edited by famed social constructionist Michel Foucault, sharpened his questions. He set on a path to find out what sexual "normality" really meant--and to find answers to the basic biology of sex differences.
Today the 40-year-old French native is one of a handful of geneticists on whom parents and doctors rely to explain how and why sex determination in an infant may have taken an unusual route. In his genetics laboratory at the University of California, Los Angeles, Vilain's findings have pushed the field toward not only improved technical understanding but more thoughtful treatment as well. "What really matters is what people feel they are in terms of gender, not what their family or doctors think they should be," Vilain says. Genital ambiguity occurs in an estimated one in 4,500 births, and problems such as undescended testes happen in one in 100. Altogether, hospitals across the U.S. perform about five sex-assignment surgeries every day.
Some of Vilain's work has helped topple ancient ideas about sex determination that lingered until very recently. Students have long learned in developmental biology that the male path of sex development is "active," driven by the presence of a Y chromosome. In contrast, the female pathway is passive, a default route. French physiologist Alfred Jost seemed to prove this idea in experiments done in the 1940s, in which castrated rabbit embryos developed into females.Terms such as "hermaphrodite" and "intersex" are vague and hurtful Vilain says.
In 1990, while at the University of Cambridge, Peter Goodfellow discovered SRY, a gene on the Y chromosome hailed as the "master switch." Just one base pair change in this sequence would produce a female instead of a male. And when researchers integrated SRY into a mouse that was otherwise chromosomally female, an XX fetus developed as a male.
But studies by Vilain and others have shaped a more complex picture. Instead of turning on male development directly, SRY works by blocking an "antitestis" gene, he proposes. For one, males who have SRY but two female chromosomes range in characteristics from normal male to an ambiguous mix. In addition, test-tube studies have found that SRY can repress gene transcription, indicating that it operates through interference. Finally, in 1994, Vilain's group showed that a male could develop without the gene. Vilain offers a model in which sex emerges out of a delicate dance between a variety of promale, antimale, and possibly profemale genes.
Because researchers have long viewed the development of females as a default pathway, the study of profemale genes has taken a backseat. Over the past few years, though, geneticists have uncovered evidence for active female determination. DAX1, on the X chromosome, seems to start up the female pathway while inhibiting testis formation--unless the gene has already been blocked by SRY. With too much DAX1, a person with the XY complement is born a female. Vilain's group found that another gene, WNT4, operates in a similar way to promote the formation of a female. The researchers discovered that these two work together against SRY and other promale factors. "Ovary formation may be just as coordinated as testis determination, consistent with the existence of an ovarian switch,' " report geneticist David Schlessinger and his collaborators in a 2006 review in the journal Bioessays.
[646 words]
Source: Science American
http://www.scientificamerican.com/article/going-beyond-x-and-y/ |
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