To buttress their case that caffeine acts instead by preventing adenosine binding, Snyder et al compared the stimulatory effects of a series of caffeine derivatives with their ability to dislodge adenosine from its receptors in the brains of mice. "In general,” they reported, “the ability of the compounds to compete at the receptors correlates with their ability to stimulate locomotion in the mouse; i.e., the higher their capacity to bind at the receptors, the higher their ability to stimulate locomotion.” Theophylline, a close structural relative of caffeine and the major stimulant in tea, was one of the most effective compounds in both regards. 这里的both regards应当指示哪里呢? 应指示前面所说的内容,尤其是前一句中所讨论的内容。 到底是哪两方面呢? 前一句,"In general,” they reported, “(1)the ability of the compounds to compete at the receptors correlates with (2)their ability to stimulate locomotion in the mouse; i.e., the higher (1)their capacity to bind at the receptors, the higher (2)their ability to stimulate locomotion.”应该就是上述括号中所标出的两个方面。 |