陈虎平36套Exercise19 第二题求助

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The common cold, produced most often by rhinoviruses, is intractable to antiviral defense. A defense against rhinoviruses might nonetheless succeed by exploiting hidden similarities among the rhinovirus strains. For example, most rhinovirus strains bind to the same kind of molecule (delta-receptors) on a cell‘s surface when they attack human cells. Colonno, taking advantage of these common receptors, devised a strategy for blocking the attachment of rhinoviruses to their appropriate receptors. Rather than fruitlessly searching for an antibody that would bind to all rhinoviruses, Colonno realized that an antibody binding to the common receptors of a human cell would prevent rhinoviruses from initiating an infection. Because human cells normally do not develop antibodies to components of their own cells, Colonno injected human cells into mice, which did produce an antibody to the common receptor. In isolated human cells, this antibody proved to be extraordinarily effective at thwarting the rhinovirus. Moreover, when the antibody was given to chimpanzees, it inhibited rhinoviral growth, and in humans it lessened both the severity and duration of cold symptoms.

2. It can be inferred from the passage that the purpose
of Colonno‘s experiments was to determine whether
(A) chimpanzees and humans can both be infected
by rhinoviruses
(B) chimpanzees can produce antibodies to human
cell-surface receptors
(C) a rhinovirus‘ nucleic acid might be locked in
its protein coat
(D) binding antibodies to common receptors
could produce a possible defense against
rhinoviruses
(E) rhinoviruses are vulnerable to human anti-
bodies

首先这个Colonno‘s experiments指的是哪个实验？是末尾那句么？那它的目的不应该是前面那句么？也就是验证antibodies的有效性，那应该是选E啊？
为什么我看见的答案和解析版全都是根据"Colonno realized that an antibody binding to the common receptors of a human cell would prevent rhinoviruses from initiating an infection"选D

wushui55

整篇文章你都没看明白。感冒的发病机制：most rhinovirus strains bind to the same kind of molecule (delta-receptors) on a cell‘s surface when they attack human cells  那么colonno就想能不能有这么个东西，在rhinovirus bind 上人细胞表面前，先bind上去，这样rhinovirus 就bind不上去了（对应文中blocking那句）。这个东西就可以叫一种antibody。至此对应D选项。E错的太离谱了，如果E是对的，那么人们就天生不会患感冒。最后解释下文中后面的实验。collono想要获得这种抗体，但是人体内是不会产生这种抗体的，（human cells normally do not develop antibodies to components of their own cells）， 他想了一个巧妙的方法，就是把人细胞注射到老鼠体内，老鼠会产生这种抗体，分离出这种抗体后，猩猩和人都可以用来治感冒。

wangzhi123139

wushui55 发表于 2013-8-15 10:36
整篇文章你都没看明白。感冒的发病机制：most rhinovirus strains bind to the same kind of molecule (del ...

非常感谢！也就是说E错在"human"这里吧？如果把human去掉就应该对了吧？