OG11-28 关于refer to 和reference用法的疑问

swimswan

28. In reference to the current hostility toward smoking smokers frequently expressed anxiety that their prospects for being hired and promoted are being stunted by their habit．
(A)In reference to the current hostility toward smoking，smokers frequently expressed anxiety that
(B)Referring to the current hostility toward smoking，smokers frequently expressed anxiety about
(C)When referring to the current hostility toward smoking，smokers frequently express anxiety about
(D)With reference to the current hostility toward smoking，smokers frequently expressed anxiety about
(E)Referring to the current hostility toward smoking，smokers frequently express anxiety that

正确选项是E

有两个问题：
1.in reference to和with reference to 是正确的吗？
2.E的逻辑主语是是sokers，那把从句补全就应该是 smokers are referring to, smokers作为refer 的发起者，似乎将不过去啊

confused,求高手指点

swimswan

第二个问题已经解决，因为refer to有“谈到”的意思，所以smoker可以作为该动作的发起者