We are not sure whether the comparision is for "light" or for "sources". So the choice could be either C or D.
Now, let us examine C
C has used "that". So logically "that" is referring singular noun-"light". If we replace "that" with "light", the sentence becomes
The Hubble Space Telescope will capture light .....twenty times fainter
than light can be detected by ground-based instruments.
This sentence is awkward.
We need some construction similar to
The Hubble Space Telescope will capture light .....twenty times fainter
than that [light] which can be detected by ground-based instruments.Now, let us see D,
D uses plural "those". So logically "those" is referring plural noun-"sources".
The Hubble Space Telescope will capture light from sources twenty times fainter
than those [sources] that can be detected by ground-based instruments.This sentence is OK. So D should be answer.