问大家一道语法题

jy02789870

Balzac drank more than fifty cups of coffee a day and died of caffeine poisoning; furthermore, caffeine did not seem to bother Samuel Johnson, the great writer and lexicographer, who was reported to have drunk twenty-five cups of tea at one sitting.
(A) furthermore, caffeine did not seem to bother
(B) however, caffeine did not seem to bother
(C) however, caffeine did not seem to have bothered
(D) furthermore, caffeine did not seem to have bothered
(E) in addition, caffeine did not seem to bother

我知道答案是b,我想问的是在什莫情况下用 to have