it 和 its 指代的可以不是一个东西吗

rainbowmanutd

1.             Although the bite of brown recluse spiders are rarely fatal, theycause chronic flesh wounds, posing the greatest danger to the infant andelderly, who are particularly vulnerable to its poison.
(A) brown recluse spiders are rarely fatal, they cause chronic fleshwounds, posing the greatest danger to the infant and elderly, who areparticularly vulnerable to its
(B) brown recluse spiders are rarely fatal, they cause chronic fleshwounds and pose the greatest danger to the infant and elderly, who areparticularly vulnerable to their
(C) the brown recluse spider israrely fatal, it causes chronic flesh wounds, posing the greatest danger to theinfant and elderly, who are particularly vulnerable to their
(D)the brown recluse spider is rarely fatal, it causes chronic flesh wounds andposes the greatest danger to infants and the elderly, who are particularlyvulnerable to its（D）
(E) the brown recluse spider is rarely fatal, they cause chronic fleshwounds, posing the greatest danger to the infant and elderly, who areparticularly vulnerable to its


比如这个，选D, it 和its 指代的不一样， it 指代bite, its指代spider's


那one 和ones, 是不是也可以指代不一样的东西？