请教一道语法题

The investigations of many psychologists and anthropologists support the generalization of there being little that is a significant difference in the underlying metal processes manifested by people from different cultures.

(A)    of there being little that is a significant difference

(B)    of there being little that is significantly different

(C)    of little that is significantly different

(D)    that there is little that is significantly different

(E)     that there is little of significant differences

答案是D，C和E是什么问题？