大全section B-19

        Balzac drank more than fifty cups of coffee a day and died of caffeine poisoning; furthermore, caffeine did not seem to bother Samuel Johnson, the great writer and lexicographer, who was reported to have drunk twenty-five cups of tea at one sitting.

(A) furthermore, caffeine did not seem to bother

(B) however, caffeine did not seem to bother

(C) however, caffeine did not seem to have bothered

(D) furthermore, caffeine did not seem to have bothered

(E) in addition, caffeine did not seem to bother

请问这里需要表示出seem和bother的时间前后吗？

choose b

"to have done" seems not idiomatic