885-B-19 "seem to have bothered"

19. Balzac drank more than fifty cups of coffee a day and died of caffeine poisoning; furthermore, caffeine did not seem to bother Samuel Johnson, the great writer and lexicographer, who was reported to have drunk twenty-five cups of tea at one sitting.
(A) furthermore, caffeine did not seem to bother
(B) however, caffeine did not seem to bother
(C) however, caffeine did not seem to have bothered
(D) furthermore, caffeine did not seem to have bothered
(E) in addition, caffeine did not seem to bother
ANSWER: B
为什么C不对？

Caffeine didn't seem to bother S who (was reported to )have drunk 25 cups of tea at one sitting.

i totally lost. here, how can 'who have drunk' used with didn't seem to ?

why use "have drunk 25 cups", but not use" who drunk 25 cups of tea at one sitting"

help me please!