求助

GWD-24-13

Vivien Thomas, who had no formal medical training, in struggling against overwhelming odds, he became a cardiac surgeon and eventually to receive an honorary doctorate from Johns
                Hopkins
                University.

1. who had no formal medical training, in struggling against over whelming odds, he became

2. having had no formal medical training, in struggling against overwhelming odds to become

3. who, having no formal medical training, he struggled against overwhelming odds in becoming

4. who, having had no formal medical training and struggled against overwhelming odds, became

5. who had no formal medical training, struggled against overwhelming odds to become

 答案是E,我选D为什么不对啊