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发表于 2014-8-5 22:30:11
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Part II: Speed
Ebola in Uganda: Why Can't We Cure It? Where Does It Hide?
Contagious fever may "hide out" in bats and birds, expert suggests.
BY Ker Than | 31 July, 2014
[Time 2]
The latest Ebola occurrence is thought to have started in Uganda's western Kibaale District about three weeks ago, but was confirmed only last Friday.
The outbreak initially went undetected, because patients did not show typical Ebola symptoms, such as hemorrhaging, and because they had other illnesses, such as malaria, which complicated diagnosis, according to Ugandan officials.
Among the 14 dead are a medical clinic officer and her four-month-old baby, as well as 9 members from a single family. A dozen others suspected to be infected have been admitted to the local hospital, according to the Washington Post.
This is not the first time Ebola has struck Uganda: In 2007 an outbreak killed 42 people, and an epidemic in 2000 killed more than 200.
The virus is still so mysterious that no one knows how it originated, in which species it hides out between epidemics, or how to treat it. There's also a lack of understanding of how Ebola is transmitted, as Uganda's president demonstrated in a national address Monday.
"We discourage the shaking of hands, because that can cause contact through sweat which can cause problems ... and avoid promiscuity, because these sicknesses can also be transmitted through sex," Yoweri Museveni said in the address.
But the idea that Ebola can be spread by shaking hands—via sweat—is a myth, according to Joseph Fair, vice president of Metabiota, a San Francisco-based company that studies Ebola and other pathogens.
"Ebola is not currently known or thought to be transmitted by perspiration," Fair said. Ebola is transmitted by bodily fluids.
Overall, "being more aware of your surroundings and mindful of your contacts is always recommended if you live in the area of an outbreak."
[283 words]
[Time 3]
Incredibly Lethal Virus
First reported in 1976 in the Democratic Republic of the Congo, Ebola is one of the most contagious known viruses. It's also incredibly lethal, killing up to 90 percent of its victims through widespread internal—and sometimes external—bleeding.
Initial symptoms can appear seemingly benign, and include vomiting, red eyes, stomach pains, and hiccups.
Eventually the virus causes capillaries—tiny, branching blood vessels throughout the body—to leak, Fair explained.
"You essentially lose the junctures between your cell walls, so your capillaries are leaking. Once that happens, you lose blood pressure and you essentially die of shock ... It's an extremely uncomfortable death."
What's more, the few people who survive Ebola often find themselves treated as outcasts by neighbors who fear the survivors still carry the disease, even though the infection is not chronic like HIV.
"While HIV-prevention-and-education campaigns have been very effective, one unforeseen effect is that people think every infection is a chronic one that will be with you for life," Fair said.
Ebola Origins a Mystery
Discovering Ebola's host or hosts—called natural reservoirs—could also help scientists predict outbreaks and develop safety measures.
Some scientists have suggested that bats are Ebola's natural reservoirs, and there is some evidence to support this theory. For example, when researchers have injected bats with the Ebola virus in experiments, the bats have survived.
But Ebola's protein structure also shares curious similarities with retroviruses carried by birds, leading some researchers to suspect the virus might have an avian origin.
One possible scenario is that Ebola evolved in birds in the distant past and was transmitted to bats, which now pass the virus on to humans and primates, said David Sanders, an Ebola researcher at Purdue University in Indiana.
It could even be that Ebola hides out in bats and birds.
"I am not opposing the idea that bats are a natural reservoir," Sanders said, "but I do not think birds have been or should be ruled out as a past host or even as a current host."
Ebola would not be the first virus to have a complicated past. The influenza virus, for example, originally infected only birds, but then jumped to humans, who might have then passed it on to pigs, Sanders said.
Now humans can catch the flu from both birds and pigs, as evidenced by the 2009 swine flu outbreak.
[395 words]
[Time 4]
Ebola Vaccine on Horizon?
Despite being first reported nearly 40 years ago, there is still no treatment or cure for Ebola.
One reason is that Ebola is not a single virus but five different strains, or species. And as with influenza and HIV, each species of Ebola carries different surface proteins that can be targeted by our immune systems.
"Therefore, if you happen to mount an immune response against species 1 of Ebola, it would most likely not be protective against species 2, 3, 4, and 5," Sanders explained.
Sanders thinks the disease's limited scope is another reason no Ebola vaccine currently exists.
"How many Americans have died of Ebola? ... The answer is zero," he said. "We tend to focus on those diseases that affect us the most."
But the likelihood is greater that an Ebola vaccine might soon be developed, as the U.S. military is concerned Ebola could be used for bioterrorism.
"A lot of researchers have come into the field since 9/11," Sanders said. "It's clearly on the [U.S.] Department of Defense's radar."
And it's not just the U.S. military that's interested in biodefense, Metabiota's Fair noted. Other federal agencies, including the U.S. Department of Agriculture, the National Institutes of Health, and the Department of Homeland Security have increased their biodefense budgets in the wake of 9/11. The European Union, Japan, and other countries have followed suit.
If military-funded research does lead to the successful development of an Ebola vaccine, it could ultimately benefit countries such as Uganda when the next natural outbreak strikes, the experts say.
"There's little doubt in my mind that advances in vaccines that are biodefense-oriented will have implications for defense against natural [Ebola] outbreaks," Sanders said.
"This is the way science works. You focus on one particular approach, but there are spin-offs for other things."
[303 words]
Source: news.nationalgeographic
http://news.nationalgeographic.com/news/2012/07/120731-ebola-uganda-virus-health-world-science/
Liberia Closes Most Borders to Contain Ebola
BY VOA| 30 July, 2014
[Time 5]
Last weekend, the president of Liberia announced measures to try to contain the Ebola virus. President Ellen Johnson Sirleaf said that her country is closing most of its borders. The few entry points that will remain open are Monrovia's international airport, a provincial airport and three major over-land border crossings. She said all these entry points will have prevention and testing centers. She added that the Liberia Airport Authority will inspect all incoming and outgoing passengers. The government has also banned public gatherings and demonstrations.
In another development, health officials are attempting to identify who came into contact last week with a man who later died of the Ebola virus. Patrick Sawyer was 40 years old, and served as an advisor to Liberia's Finance Ministry. Mr. Sawyer took a flight from Liberia to Ghana. He later changed airplanes in Togo for a flight to Nigeria, where he died last Friday. Witnesses said he was sick on at least one of his flights. He reportedly was vomiting and had diarrhea. The expulsion of food from the stomach, and body wastes are signs of the disease.
Patrick Sawyer was going to Nigeria for a conference. He planned to go to the United States to visit with his wife and children.
On Monday, Nigerian officials announced that they had identified more than 50 people who came into contact with Mr. Sawyer. But some fear many more may have had contact with him than is currently known.
Jide Idris is Health Commissioner in Lagos State. He says both the health and aviation departments are searching for other possible Ebola cases.
"We call on all Nigerians to be calm, and not panic and do hereby ensure them that both the state and the federal government are up in arms to ensure that the virus does not escape and that no Nigerian is infected with this virus."
Ebola has killed about 700 people across West Africa this year. More than 1,200 others have been infected. Health workers say an outbreak in Lagos, Nigeria's largest city, would be an almost unimaginable disaster.
Experts from the United States Centers for Disease Control and Prevention are in West Africa. They are working with government ministries and international organizations to follow the spread of Ebola cases.
[376 words]
[Time 6]
In the past, the Ebola virus currently active in Liberia, Guinea and Sierra Leone killed 90 percent of those who got sick. The CDC says the death rate for the current outbreak is about 60 percent. Experts say this shows that early treatment is having an effect.
Stephan Monroe studies emerging diseases for the Centers for Disease Control. He spoke during a conference from the CDC's headquarters in Atlanta, Georgia.
"We know how to stop the outbreak and that is to break the chains of transmission. And so what does that involve? It involves first identifying cases through active case findings, and then identifying all of their contacts -- who had contact with them during the time when they were symptomatic, and therefore are at risk of becoming infected themselves, and following those contacts daily for 21 days and if they do develop symptoms, to get them into one of these isolation facilities."
Stephan Monroe says fear and misinformation are preventing some people from seeking treatment. He says what the CDC and health organizations are hoping to do is to find trusted members of the affected communities to publicize how to contain the disease.
[194 words]
Source: VOA
http://www.51voa.com/VOA_Special_English/liberia-close-borders-contain-ebola-virus-57951.html
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