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发表于 2014-1-20 22:21:10
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Part II:Speed
Thinking hard weighs heavy on the brain
by Laura Sanders 10:22am, January 17, 2014
[Time 2]
When the mind is at work, the brain literally gets heavier.
That fact may be surprising, but it isn’t new: In the late 1880s, Italian scientist Angelo Mosso built an intricate full-body balance and reported that mental activity tips the scales. Now, a modern-day version of Mosso’s “human circulation balance” backs him up. Compared with a brain at rest, a brain listening to music and watching a video is indeed heavier, David Field and Laura Inman of the University of Reading in England report January 9 in Brain.
While teaching a course about brain-imaging techniques, Field grew curious whether Mosso’s general approach would work. So he and some students decided to find out. “It was a bit of a mad idea, to be honest,” Field says.
At the heart of both balances lies a simple seesaw lever. As weight shifts in a body, presumably from blood moving, the lever tilts the head or the feet downward, Mosso observed. Field and Inman’s contraption doesn’t actually tip. The researchers put a sensitive scale under the head end, which would register changes in force.
After lots of troubleshooting, which involved eliminating signals created by bodily processes that move blood such as breathing and heart beats, Field and Ingram were able to test mental tasks. Fourteen participants were asked to lie still on the lever, and listen to music or listen to music and simultaneously watch a video of colorful geometric shapes. The part of the brain that detects sound is relatively small, Field says, so the audio plus video test was used to activate a wider swath of the brain and increase the chances of a measurable blood shift.
Right after a two-second blip of either audio or audio and video, blood leaves the brain, as measured by a drop in force, Field and Inman found. This quick dip in blood volume, a phenomenon that’s also seen in functional MRI, may represent the brain preparing for work by shunting waste-ridden blood out via the jugular vein. Seconds after that, a surge of new blood enters the brain, increasing the force measured by the scale.
[351 words]
[Time 3]
These changes in force were very small — about 0.005 newtons — and most prominent in the people who both listened to music and watched a video, Field says. It’s hard to calculate how much blood rushes into the brain with each mental task. To know that value, scientists would need to know the distance of the head from the lever’s fulcrum, which could be easily measured, and exactly where the blood came from, which is nearly impossible to know.
In his original experiments, Mosso found that tasks that required more mental energy made the brain heavier. Reading a page from a mathematics manual seemed to tip the balance more than reading a page from a newspaper. Strong emotions also tipped the scales: When a subject read a letter from an angry creditor, Mosso wrote, “the balance fell at once.”
Until recently, Mosso’s scientific manuscripts had not been described in detail. But Stefano Sandrone of King’s College London unearthed Mosso’s papers in archives and published a description in Brain in 2013.
“We have been neglecting Mosso and his work for so many years. It’s good that someone has begun to find interest in the papers that he wrote,” Sandrone says of the modern-day experiment. He and his colleagues are working on an exhibition of Mosso’s original balance.
Many neuroscientists use functional MRI to detect changes in blood flow in the brain. Usually, fMRI spots regional differences, as when a little blood moves from one part of the brain to another. In contrast, the balance describes overall changes in brain workload, Field says.
The balance is not going to replace modern neuroimaging as a way to see what happens inside the brain. But with refinements, it might ultimately prove to be useful, Sandrone says. “The more measures we have, the more we can approximate the complexity of the brain.”
[307 words]
Source:Science News
https://www.sciencenews.org/article/thinking-hard-weighs-heavy-brain
Baby-cam captures an infant’s world
by Laura Sanders 5:52pm, January 13, 2014
[Time 4]
If you’re curious about what your cat sees all day, you can strap a cat-cam to its collar. The tiny video camera assumes the vantage point of the cat as it swishes through tall grass, sits at the window and laps up water. These cameras aren’t just for kitties, either. The artist Sam Easterson has used the tiny head-mounted cameras to capture the perspectives of turkeys, tarantulas, buffalo, armadillos and even a wayward tumbleweed.
So it seems funny to me that no one had thought to slap a head camera on a newborn baby. Luckily, researchers from Ryerson University in Toronto are on it. Nicole Sugden and colleagues recently developed the arguably cutest cam in existence: a happy face camera affixed to a headband for tiny little babies. “While we had parents’ perspectives on what infants are exposed to, we didn’t have any idea about what the world looked like from an infant perspective,” Sugden says.
Their study, published in November in Developmental Psychobiology, recorded the first-person perspectives of 14 1-month-old babies and 16 3-month-old babies for two weeks. Parents were asked to put the headbands on the infants whenever Baby was awake and not fussy.
Compared with a tumbleweed’s thrilling existence, much of the baby footage was pretty boring: changing, feeding and playing. But these mundane moments were occasionally punctuated with excitement: The baby goes out to dinner in a restaurant! The baby drops in to see her sister’s recital! The baby hits the library! These cameras caught it all, amassing an impressive collection of people pulling hilarious faces to make babies smile. Some scenes suggested that the families forgot the cameras were rolling. Judging from some questionable attire choices, Sugden suspects that some moms forgot to tell the dads when the cameras were on.
After the footage made it back to Ryerson University, the scientists noticed that of many of these different scenes had a common element that loomed large in the infants’ field of vision: faces. Babies spent a whopping quarter of their time in the presence of a face, the researchers found. In contrast, adults are exposed to real faces only about 7 or 8 percent of their time (T.V., Facebook and billboard faces didn’t count), Sugden says.
[372 words]
[Time 5]
Most of the faces belonged to adult women of the same race as the baby, usually the mother. Notable exceptions came from babies with older brothers, a baby with a really involved father and one baby boy who spent marathon sessions gazing at himself soothingly in mirrors. (This little guy’s own face accounted for more than 90 percent of his face-viewing time.)
This extensive face gazing probably helps babies perceive faces better. And not just any faces. Babies are born pretty good at discerning a wide variety of faces. But as they get older, babies lose this general ability through a process called perceptual tuning. Through their experience with their environment and caregivers, babies learn that some faces are more important than others, and focus their attention on them. This process makes them worse at discriminating features on faces they rarely see.
Sugden and her colleagues think that the faces they caught on their baby-cams are probably tuning these infants’ brains, keying them in to features on familiar faces, a skill that ultimately comes at the expense of perceiving other faces. It would be interesting to know how these babies ultimately fare, and whether the babies who saw a more diverse crowd of faces had different perceptual tuning effects later on.
Beyond faces, there’s no telling what else these baby-cams could detect. The baby-cams could capture how language skills relate to the vocabulary a baby hears, how allergies relate to pet exposure, how motor skills relate to time spent rolling around on the floor. And parents themselves might want in on the action. “Outside of science, parents could actually do this themselves to get a glimpse of their baby’s view of the world,” Sugden says. “I would imagine it being a nifty addition to anyone’s baby book.”
[297 words]
Source:Science News
https://www.sciencenews.org/blog/growth-curve/baby-cam-captures-infants-world
Life at the Speed of Light
by Alexandra Witze 10:20am, January 16, 2014
[Time 6]
Biology has come a long way from the days of mixing things in petri dishes and hoping something interesting happens. In his new book, Venter introduces readers to a future of precise biological engineering, guided by DNA and targeted to create life forms never before thought possible.
Venter has the scientific chops to back up these claims. His first book related the story of how he led a private effort that raced a government-funded consortium to decipher the DNA sequence that makes up the human genome. His second book focuses on a later lab triumph: the creation of Synthia, the first life-form with a synthesized genome.
Synthia, announced in 2010, is a bacterial mash-up. Venter’s team stitched together a genetic code for one bacterial species from scratch, then inserted it into a second species and booted it up. The result was a living, self-replicating cell that essentially cribbed synthetic DNA to function.
In relating Synthia’s story, Venter illuminates the twists and turns that are a hallmark of modern science. Time and again the researchers go down blind alleys, only to start again using a different tack — such as ditching one simple but slow-growing bacterial species in favor of another more complex one that will replicate faster in petri dishes.
This description of science-as-process is perhaps the most notable aspect of Life at the Speed of Light. Venter embeds the story of Synthia in the deep history of molecular biology, laying out discoveries by previous generations of scientists and clarifying how those advances made way for modern investigations. It’s a story with many blind turns and dead ends, but one that triumphs in the end.
[274 words]
Source:Science News
https://www.sciencenews.org/article/life-speed-light
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