Vivien Thomas, who had no formal medical training, in struggling against overwhelming odds, he became a cardiac surgeon and eventually to receive an honorary doctorate from Johns Hopkins University.
A) who had no formal medical training, in struggling against overwhelming odds, he became B) having had no formal medical training, in struggling against overwhelming odds to become C) who, having no formal medical training, he struggled against overwhelming odds in becoming D) who, having had no formal medical training and struggled against overwhelming odds, became (E) E) who had no formal medical training, struggled against overwhelming odds to become