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| Even after long periods of sleep when adenosine is at its lowest concentration in the brain, the number of brain cells bound with adenosine remains very large. |
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| Caffeine, which has the effect of making people remain wakeful, is known to interfere with the binding of adenosine to sites on brain cells. |
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| Besides binding to sites in the brain, adenosine is known to be involved in biochemical reactions throughout the body. |
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| Some areas of the brain that are relatively inactive nonetheless release some adenosine. |
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| Stress resulting from a dangerous situation can preserve wakefulness even when brain levels of bound adenosine are high. |